Fig. 1 · Structure
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AGX51
Pan-Id Antagonist
AGX51 is a first-in-class pan-Id antagonist that targets inhibitors of DNA-binding/differentiation proteins. By disrupting the Id1-E47 interaction, AGX51 promotes ubiquitin-mediated degradation of Id proteins, resulting in cell growth arrest and reduced viability. This compound demonstrates significant anti-tumor activity against triple-negative breast cancer (TNBC) with an IC50 of approximately 25 nM, making it a valuable tool for cancer research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 330834-54-3 |
| Applications | Pan-Id Antagonist |
| Formula | C27H29NO4 |
| Molecular Weight | 431.52 |
| SMILES | CCC(N(CCC(C1=CC=C(OCO2)C2=C1)C3=CC=CC=C3OC)CC4=CC=CC=C4)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.