AH-7614 is a selective antagonist of FFA4 (GPR120), exhibiting potent inhibition with pIC50 values of 7.1, 8.1, and 8.1 for human, mouse, and rat FFA4, respectively. This compound demonstrates high specificity for FFA4 over FFA1, with a pIC50 value lower than 4.6. AH-7614 effectively blocks the biological effects induced by both linoleic acid, a polyunsaturated ω-6 fatty acid, and synthetic FFA4 agonists, making it a valuable tool for research on metabolic processes and signaling pathways associated with fat metabolism.
AH-7614 is a selective antagonist of FFA4 (GPR120), exhibiting potent inhibition with pIC50 values of 7.1, 8.1, and 8.1 for human, mouse, and rat FFA4, respectively. This compound demonstrates high specificity for FFA4 over FFA1, with a pIC50 value lower than 4.6. AH-7614 effectively blocks the biological effects induced by both linoleic acid, a polyunsaturated ω-6 fatty acid, and synthetic FFA4 agonists, making it a valuable tool for research on metabolic processes and signaling pathways associated with fat metabolism.
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