Fig. 1 · Structure
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AI-4-57
CBFβ-RUNX1 Inhibitor
AI-4-57 is an allosteric inhibitor targeting the CBFβ-RUNX1 interaction, specifically disrupting the binding between core binding factor β and smooth muscle myosin heavy chain. With an IC50 of 22 μM, AI-4-57 serves as a valuable tool for research into hematologic malignancies and other conditions involving dysregulation of this pathway. Its efficacy in modulating the CBFβ-RUNX1 complex makes it suitable for studies related to gene expression and cellular differentiation in hematopoietic cells.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 63053-14-5 |
| Applications | CBFβ-RUNX1 Inhibitor |
| Formula | C13H11N3O |
| Molecular Weight | 225.25 |
| SMILES | COC1=CC=C2N=C(C3=NC=CC=C3)NC2=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.