Fig. 1 · Structure
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AICA-riboside, 5′-phosphate
Analogue of AICAR
AICA-riboside, 5′-phosphate is a phosphorylated analogue of AICAR that functions primarily as an AMP mimetic, selectively activating AMP-activated protein kinase (AMPK). It enhances the extracellular concentration of adenosine by competing with adenosine for uptake via nucleoside transporters, which can indirectly activate adenosine A1 receptors. This compound plays a significant role in metabolic regulation by promoting catabolism and inhibiting anabolism, as well as providing adenosine-dependent neuroprotection, making it relevant for research in metabolic disorders such as diabetes and obesity, as well as neurological conditions like ischemia and epilepsy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 3031-94-5 |
| Applications | Analogue of AICAR |
| Formula | C9H15N4O8P |
| Molecular Weight | 338.21 |
| Synonyms | AICAR-5'-MP |
| SMILES | O[C@@H]1[C@@H](COP(O)(O)=O)O[C@@H](N2C(N)=C(C(N)=O)N=C2)[C@@H]1O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.