Fig. 1 · Structure
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AJM 290
Trx-1 Inhibitor
AJM 290 is a selective inhibitor of Trx-1, targeting the HIF-1α COOH-terminal transactivation domain. It effectively blocks the binding of HIF-1 to DNA, thereby modulating hypoxic responses. This compound serves as a valuable tool for studying the role of redox regulatory mechanisms in cancer and other diseases related to hypoxia.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 840474-95-5 |
| Applications | Trx-1 Inhibitor |
| Formula | C20H14FNO4S |
| Molecular Weight | 383.39 |
| SMILES | O=C1C=CC(C=C1)(C2=CC3=C(N2S(=O)(C4=CC=CC=C4)=O)C=C(F)C=C3)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.