Fig. 1 · Structure
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AK-778-XXMU
ID2 Antagonist
AK-778-XXMU is a potent antagonist of Inhibitor of DNA Binding 2 (ID2) with a binding affinity of KD 129 nM. This compound effectively inhibits the migration and invasion of glioma cell lines, induces apoptosis, and demonstrates significant anticancer activity. AK-778-XXMU targets the ID2-KDR signaling pathway, resulting in the down-regulation of angiogenic factors like VEGFA and invasion-related proteins such as MMP2/9, while concurrently up-regulating the tumor suppressor PTEN. This reagent is suitable for investigating the molecular mechanisms underlying glioma progression.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1227045-76-2 |
| Applications | ID2 Antagonist |
| Formula | C22H17ClN2O3 |
| Molecular Weight | 392.83 |
| SMILES | O=C(C1=CC=CC=N1)CC2(C(N(C3=C2C=CC=C3)CC4=CC=CC(Cl)=C4)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.