Fig. 1 · Structure
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AKI603
AurA Inhibitor
AKI603 is a selective inhibitor of Aurora kinase A (AurA), demonstrating an IC50 of 12.3 nM. This compound is specifically designed to target resistance associated with the BCR-ABL-T315I mutation. AKI603 shows significant anti-proliferative effects in leukemic cells, making it a valuable tool for research focused on overcoming treatment resistance in hematological malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1432515-73-5 |
| Applications | AurA Inhibitor |
| Formula | C19H23N9O2 |
| Molecular Weight | 409.45 |
| SMILES | O=[N+]([O-])C1=CC=C(C=C1)NC2=NC(N3CCN(CC3)C)=CC(NC4=NNC(C)=C4)=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.