Fig. 1 · Structure
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AKR1B10-IN-1
AKR1B10 Inhibitor
AKR1B10-IN-1 is a potent inhibitor of Aldo-Keto Reductase 1B10 (AKR1B10), exhibiting an IC50 value of 3.5 nM. This compound demonstrates the ability to suppress cell proliferation, metastasis, and resistance to Cisplatin (CDDP) in lung cancer cells. AKR1B10-IN-1 is valuable for researchers investigating therapeutic strategies for lung cancer treatment and understanding the role of AKR1B10 in cancer biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2136579-33-2 |
| Applications | AKR1B10 Inhibitor |
| Formula | C19H16FNO4 |
| Molecular Weight | 341.33 |
| SMILES | O=C(C1=CC2=CC=C(O)C=C2OC1=O)NCCCC3=CC=C(F)C=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.