Fig. 1 · Structure
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AKR1C3-IN-12
AKR1C3 Inhibitor
AKR1C3-IN-12 is a potent inhibitor of aldo-keto reductase 1C3 (AKR1C3), demonstrating an IC50 value of 27 nM. This compound has been shown to enhance the effectiveness of chemotherapeutic agents such as Gemcitabine and Cisplatin in the treatment of bladder cancer. Its application underscores the potential of targeting AKR1C3 in cancer therapy research and the development of combination treatments.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 891075-67-5 |
| Applications | AKR1C3 Inhibitor |
| Formula | C17H14N2O3 |
| Molecular Weight | 294.30 |
| SMILES | O=C(C1=CC2=C(OC1=N)C(O)=CC=C2)NC3=CC=C(C)C=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.