Fig. 1 · Structure
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AKR1C3-IN-14
AKR1C3 Inhibitor
AKR1C3-IN-14 is a potent inhibitor of the aldo-keto reductase 1C3 (AKR1C3) enzyme, with an IC50 value of 0.122 μM. By inhibiting AKR1C3 activity, this compound effectively reduces the overproduction of androgens, which plays a crucial role in hormone-mediated signaling pathways. Additionally, AKR1C3-IN-14 is involved in the biosynthesis of the prostaglandin PGF2α, influencing cell proliferation. This compound is valuable for investigating prostate cancer and understanding its hormonal regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1057882-82-2 |
| Applications | AKR1C3 Inhibitor |
| Formula | C21H21BrN2O4 |
| Molecular Weight | 445.31 |
| SMILES | O=C(NC1=CC=C(Br)C=C1C)CN(C)CC(C2=C(O3)C(C)=C(O)C=C2)=CC3=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.