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AKR1C3-IN-5

AKR1C3 Inhibitor

AKR1C3-IN-5 is a potent inhibitor of the AKR1C3 enzyme, which is often overexpressed in hormone-dependent prostate and breast tumors. This compound, a derivative of drupanin, exhibits a half-maximal inhibitory concentration (IC50) of 9.6 ± 3 μM. With a selectivity index (SI) of 5.5 against MCF-7 cells, AKR1C3-IN-5 is valuable for researchers investigating the role of AKR1C3 in cancer biology and therapeutic targeting.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2839142-93-5
Applications	AKR1C3 Inhibitor
Formula	C₃₄H₄₄N₂O₇
Molecular Weight	592.72
SMILES	CC(OC1=CC=C(C=C1C/C=C(C)\C)/C=C/C(N[C@H](C(OCC2=CC=CC=C2)=O)CCCCNC(OC(C)(C)C)=O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.