Fig. 1 · Structure
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AKR1C3-IN-6
AKR1C3 Inhibitor
AKR1C3-IN-6 is a selective inhibitor of the enzyme AKR1C3, demonstrating potent inhibitory activity with an IC50 of 0.31 μM. In contrast, it shows significantly less activity against AKR1C2 with an IC50 of 73.23 μM. This compound exhibits notable antitumor properties, making it a valuable tool for research in cancer biology and therapeutic development targeting AKR1C3-related pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2137881-54-8 |
| Applications | AKR1C3 Inhibitor |
| Formula | C18H15F3N4O3 |
| Molecular Weight | 392.33 |
| SMILES | COC1=CC=C(C=C1)CN2N=NC(O)=C2C(NC3=CC(C(F)(F)F)=CC=C3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.