Fig. 1 · Structure
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AKR1C3-IN-9
AKR1C3 Inhibitor
AKR1C3-IN-9 is a highly selective inhibitor of Aldo-keto Reductase 1C3 (AKR1C3), exhibiting an IC50 value of 8.92 nM. This compound demonstrates the ability to significantly reverse Doxorubicin resistance in resistant breast cancer cell lines, offering valuable insights into overcoming chemoresistance in cancer therapy. Its selective action on AKR1C3 makes it a valuable tool for research into metabolic regulation and therapeutic resistance mechanisms in oncology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2924824-43-9 |
| Applications | AKR1C3 Inhibitor |
| Formula | C20H20N2O4 |
| Molecular Weight | 352.38 |
| SMILES | COC1=CC=CC=C1NC(C2=CC=CC=C2OCC3=C(ON=C3C)C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.