Fig. 1 · Structure
Documents & Downloads
AKT-IN-3
Apoptosis
AKT-IN-3 is a potent and selective AKT inhibitor that primarily targets the Akt signaling pathway, exhibiting IC50 values of 1.4 nM, 1.2 nM, and 1.7 nM for Akt1, Akt2, and Akt3, respectively. This compound also demonstrates significant inhibitory activity against other AGC family kinases, including PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. AKT-IN-3 is utilized in cancer research due to its ability to induce apoptosis and inhibit metastasis in cancer cells, making it a valuable tool for exploring therapeutic strategies against malignancies.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2374740-21-1 |
| Applications | Apoptosis |
| Formula | C23H23Cl2F2N5O3 |
| Molecular Weight | 526.36 |
| SMILES | CNC(C[C@H]1NC[C@@H](NC(C2=CC(C3=C(Cl)C=NN3C)=C(Cl)O2)=O)[C@H](C4=CC(F)=C(F)C=C4)C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.