Fig. 1 · Structure
Documents & Downloads
Akuammine
Akuammine is an indole alkaloid primarily known for its analgesic activity, obtained from Picralima nitida. It selectively binds to the μ- and κ-opioid receptors, demonstrating affinities of 0.3 μM and 1.68 μM, respectively, while showing less affinity for the δ-opioid receptor (10.4 μM). Akuammine effectively inhibits forskolin-induced cAMP production in HEK293 cells expressing these opioid receptors, with IC50 values of 2.6 μM for μ-opioid and 0.073 μM for κ-opioid receptors. In vivo studies reveal that akuammine enhances pain thresholds in mice, as evidenced by increased latency in tail-flick and hot plate tests following administration at a dose of 60 mg/kg.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 3512-87-6 |
| Formula | C22H26N2O4 |
| Molecular Weight | 382.45 |
| Synonyms | (-)-Akuammine; Vincamajoridine |
| SMILES | C/C=C(C1)\[C@H]2[C@]3(C(OC)=O)CO[C@@]45N(C)C6=CC=C(O)C=C6[C@]43CCN1[C@H]5C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.