Fig. 1 · Structure
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Ala-Ala-Pro-Val-chloromethylketone
NE Inhibitor
Ala-Ala-Pro-Val-chloromethylketone is an irreversible inhibitor of human neutrophil elastase (NE), a serine protease implicated in various inflammatory processes. This compound is primarily utilized in research related to chronic inflammatory airway diseases, aiding in the investigation of NE's role in disease progression and pathology. Its inhibitory action helps elucidate the molecular mechanisms underlying inflammation and may contribute to the development of therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 90105-47-8 |
| Applications | NE Inhibitor |
| Formula | C17H29ClN4O4 |
| Molecular Weight | 388.89 |
| Synonyms | AAPV-CMK |
| SMILES | C(N[C@H](C(CCl)=O)[C@@H](C)C)(=O)[C@H]1N(C([C@@H](NC([C@H](C)N)=O)C)=O)CCC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.