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Alcudacigib

DGKζ Inhibitor

Alcudacigib is a selective inhibitor of diacylglycerol kinase zeta (DGKζ), targeting key signaling pathways involved in cellular activation. This compound exhibits significant biological activity in the modulation of immune responses, making it a valuable tool for research related to cancer immunotherapy and mechanisms of resistance to anti-PD-1 or anti-PD-L1 antibody therapies. Researchers can utilize Alcudacigib to explore its effects on immunocyte activation in cancer models.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2660218-70-0
Applications	DGKζ Inhibitor
Formula	C₂₇H₂₅F₃N₆O₂S
Molecular Weight	554.59
Synonyms	DGKζ-IN-1
SMILES	FC(F)(C1=C(N2C[C@@H](CCC2)CN)C(NC(C3=CSC(C4=CN=NC=C4)=N3)=O)=CC=C1OC5=CC=CC=C5)F

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.