Fig. 1 · Structure
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Aldoxorubicin hydrochloride
Prodrug of Doxorubicin
Aldoxorubicin hydrochloride is a prodrug of Doxorubicin, designed to enhance targeted drug delivery through albumin binding. It acts as a potent inhibitor of DNA topoisomerase II, facilitating cytotoxicity against a range of cancer cell lines. Aldoxorubicin hydrochloride demonstrates significant antitumor efficacy in various murine tumor models, making it a valuable reagent for cancer research and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1361563-03-2 |
| Applications | Prodrug of Doxorubicin |
| Formula | C37H43ClN4O13 |
| Molecular Weight | 787.21 |
| Synonyms | INNO-206 hydrochloride; DOXO-EMCH hydrochloride |
| SMILES | [H][C@@]1(O[C@H]2C[C@@](/C(CO)=N/NC(CCCCCN3C(C=CC3=O)=O)=O)(O)CC(C2=C4O)=C(O)C5=C4C(C6=C(OC)C=CC=C6C5=O)=O)O[C@@H](C)[C@@H](O)[C@@H](N)C1.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.