Fig. 1 · Structure
Documents & Downloads
Aldumastat
ADAMTS-5 Inhibitor
Aldumastat is a selective, orally active inhibitor of ADAMTS-5, exhibiting an IC50 value of 19 nM and demonstrating eight-fold selectivity over ADAMTS-4 with an IC50 of 156 nM. This compound displays significant anticatabolic activity, making it a valuable tool for researching osteoarthritis and related degenerative conditions. Its specificity and potency provide a robust platform for understanding the role of ADAMTS-5 in matrix degradation and cartilage pathology.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1957278-93-1 |
| Applications | ADAMTS-5 Inhibitor |
| Formula | C20H24F2N4O3 |
| Molecular Weight | 406.43 |
| Synonyms | GLPG1972; S201086 |
| SMILES | O=C(N(CCN1C2=CC(F)=CC(F)=C2)C[C@@H]1C)CC[C@](NC3=O)(C4CC4)C(N3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.