Alloc-Val-Ala-OH is a biochemical assay reagent that serves as a versatile building block in the synthesis of Tesirine, a clinical antibody-drug conjugate featuring a pyrrolobenzodiazepine dimer payload. This compound is specifically designed for selective cleavage by Cathepsin B, facilitating targeted therapeutic applications. The stable Alloc group withstands exposure to piperidine and TFA, yet it can be conveniently removed under mild conditions through palladium-catalyzed allyl transfer, making it suitable for various synthetic pathways in biochemical research.
Alloc-Val-Ala-OH is a biochemical assay reagent that serves as a versatile building block in the synthesis of Tesirine, a clinical antibody-drug conjugate featuring a pyrrolobenzodiazepine dimer payload. This compound is specifically designed for selective cleavage by Cathepsin B, facilitating targeted therapeutic applications. The stable Alloc group withstands exposure to piperidine and TFA, yet it can be conveniently removed under mild conditions through palladium-catalyzed allyl transfer, making it suitable for various synthetic pathways in biochemical research.
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