Alogabat is a positive allosteric modulator (PAM) of the GABAA α5 receptor, specifically targeting the α5β3γ2 subunit with a Ki of 8.7 nM. It enhances the expression of this receptor subtype in oocytes, increasing levels by 1.97-fold. Alogabat is useful in research into cognitive impairment linked to various central nervous system disorders, including Alzheimer's disease, schizophrenia, and dementia. Its role in modulating GABAA receptors makes it relevant for studying conditions such as mild cognitive impairment and age-related cognitive decline, as well as elucidating mechanisms underlying neuropsychiatric disorders.
Alogabat is a positive allosteric modulator (PAM) of the GABAA α5 receptor, specifically targeting the α5β3γ2 subunit with a Ki of 8.7 nM. It enhances the expression of this receptor subtype in oocytes, increasing levels by 1.97-fold. Alogabat is useful in research into cognitive impairment linked to various central nervous system disorders, including Alzheimer's disease, schizophrenia, and dementia. Its role in modulating GABAA receptors makes it relevant for studying conditions such as mild cognitive impairment and age-related cognitive decline, as well as elucidating mechanisms underlying neuropsychiatric disorders.
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