Fig. 1 · Structure
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Alogabat
GABAA α5 Receptor PAM
Alogabat is a positive allosteric modulator (PAM) of the GABAA α5 receptor, specifically targeting the α5β3γ2 subunit with a Ki of 8.7 nM. It enhances the expression of this receptor subtype in oocytes, increasing levels by 1.97-fold. Alogabat is useful in research into cognitive impairment linked to various central nervous system disorders, including Alzheimer's disease, schizophrenia, and dementia. Its role in modulating GABAA receptors makes it relevant for studying conditions such as mild cognitive impairment and age-related cognitive decline, as well as elucidating mechanisms underlying neuropsychiatric disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 2230009-48-8 |
| Applications | GABAA α5 Receptor PAM |
| Formula | C21H23N5O4 |
| Molecular Weight | 409.44 |
| Synonyms | RG-7816; RO-7017773 |
| SMILES | O=C(C1=NN=C(OCC2=C(C)ON=C2C3=CC=C(C)N=C3)C=C1)NC4CCOCC4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.