Fig. 1 · Structure
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Alpidem
Anxiolytic Agent
Alpidem is an orally active anxiolytic agent that selectively targets GABAA receptors, specifically those containing the α1β2γ2 subunit, with an IC50 of 17 nM. It exhibits various biological activities, including modulation of mitochondrial permeability, induction of glutathione depletion, and enhancement of feeding behavior in stressed rodents. Additionally, Alpidem demonstrates anticonvulsant properties and can inhibit marble-burying behavior. This compound is suitable for research related to anxiety, anxiety disorders, and convulsive disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 82626-01-5 |
| Applications | Anxiolytic Agent |
| Formula | C21H23Cl2N3O |
| Molecular Weight | 404.34 |
| SMILES | O=C(N(CCC)CCC)CC1=C(C2=CC=C(Cl)C=C2)N=C3C=CC(Cl)=CN31 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.