Fig. 1 · Structure
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ALR1/2-IN-1
ALR1/2 Inhibitor
ALR1/2-IN-1 is a selective inhibitor of aldehyde reductase (ALR1) and aldose reductase (ALR2), demonstrating IC50 values of 3.26 μM and 3.06 μM for ALR1 and ALR2, respectively. This compound has been shown to exhibit significant anti-cancer activity, making it a valuable tool for research in cancer biology and metabolic disorders. Its dual-targeting mechanism offers potential for further investigation in therapeutic applications related to oxidative stress and diabetic complications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2419233-57-9 |
| Applications | ALR1/2 Inhibitor |
| Formula | C18H18N4O5S2 |
| Molecular Weight | 434.49 |
| SMILES | O=C(NC1=CC=CC=C1OC)CSC2=NN=C(C3=CC=CC=C3NS(=O)(C)=O)O2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.