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Alsterpaullone

CDK inhibitor

Alsterpaullone (9-Nitropaullone;NSC 705701) is a potent CDK inhibitor, with IC50s of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively.

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Biological Activity

Target & Activity

Target	Activity	Value
Cdk1/cyclin B	IC50	35 nM
cdk2/cyclin A	IC50	15 nM
CDK2/Cyc E	IC50	200 nM
CDK5/p35	IC50	40 nM
GSK-3α	IC50	4
GSK-3β	IC50	4 nM

6 targets · Scroll to view more

Cellular Effect

Cell Line	Activity	Value	Description	Reference
DU-145	IC50	1.1 μM	Cytotoxicity against human DU145 cells after 24 hrs by MTT assay	[PMID: 20627564]
HCT-15	IC50	0.62 μM	Cytotoxicity against human HCT15 cells after 48 hrs by SRB assay	[PMID: 19217301]
K562	IC50	1.58 μM	Cytotoxicity against human K562 cells after 48 hrs by SRB assay	[PMID: 19217301]
LoVo	IC50	< 1 μM	Cytotoxicity against human LoVo cells after 24 hrs by MTT assay	[PMID: 20627564]
MCF7	IC50	1.24 μM	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 19217301]
MCF7	IC50	2.7 μM	Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 20627564]
PC-3	IC50	1.12 μM	Cytotoxicity against human PC3 cells after 48 hrs by SRB assay	[PMID: 19217301]
RAW264.7	IC50	2.2 μM	Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay	[PMID: 20627564]
U-251	IC50	0.68 μM	Cytotoxicity against human U251 cells after 48 hrs by SRB assay	[PMID: 19217301]

9 records · Scroll to view more

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	237430-03-4
Applications	CDK inhibitor
Formula	C₁₆H₁₁N₃O₃
Molecular Weight	293.28
Synonyms	9-Nitropaullone; NSC 705701
SMILES	O=C1NC2=CC=CC=C2C(NC3=C4C=C([N+]([O-])=O)C=C3)=C4C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.