Fig. 1 · Structure
Documents & Downloads
Alvelestat tosylate
Elastase Inhibitor
Alvelestat tosylate is a potent and selective inhibitor of neutrophil elastase (NE), demonstrating an affinity characterized by a pIC50 value of 7.9 nM and a Ki value of 9.4 nM. This compound plays a critical role in modulating inflammatory responses and tissue remodeling processes. It is primarily utilized in research applications focused on respiratory diseases, wherein neutrophil elastase activity contributes to pathophysiology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1240425-05-1 |
| Applications | Elastase Inhibitor |
| Formula | C32H30F3N5O7S2 |
| Molecular Weight | 717.74 |
| Synonyms | AZD9668 tosylate |
| SMILES | O=C(C1=CC(C2=CC=NN2C)=C(C)N(C3=CC=CC(C(F)(F)F)=C3)C1=O)NCC4=NC=C(S(=O)(C)=O)C=C4.O=S(C5=CC=C(C)C=C5)(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.