Fig. 1 · Structure
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AM-1488
GlyR Potentiator
AM-1488 is a potent, orally active potentiator of the glycine receptor (GlyR), with an EC50 value of 0.45 μM for the human GlyRα3 subtype. This compound enhances glycine receptor-mediated neurotransmission, making it valuable for research into synaptic signaling and neurological disorders. It is particularly relevant in studies exploring the role of glycine receptors in excitatory and inhibitory neurotransmission.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 2079895-60-4 |
| Applications | GlyR Potentiator |
| Formula | C19H17N3O4S |
| Molecular Weight | 383.42 |
| SMILES | O=C1[C@@]2([H])[C@@](CN(C2)S(=O)(C3=CC=C(OC=C4)C4=C3)=O)([H])C5=CN=CC=C5N1C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.