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Biological Activity
AM-4668 is a GPR40 agonist for type 2 diabetes. EC50s of 3.6 nM and 36 nM for GPR40 in A9 cells (GPR40 IP3 assay) and CHO cells (GPR40 aequorin assay), respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.47 mL | 102.36 mL | 204.72 mL |
| 0.5 mM | 4.09 mL | 20.47 mL | 40.94 mL |
| 1 mM | 2.05 mL | 10.24 mL | 20.47 mL |
| 5 mM | 0.41 mL | 2.05 mL | 4.09 mL |
*The above data is based on the productmolecular weight 488.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21778 |
|---|---|
| Actions | Agonist |
| CAS No. | 1011531-27-3 |
| Formula | C24H19F3N2O4S |
| M. Wt | 488.48 |
| Purity | >98% |
| Synonyms | AM 4668; AM4668 |
| SMILES | OC(C[C@H](C1=NOC=C1)C(C=C2)=CC=C2OCC(S3)=C(C)N=C3C4=CC=C(C(F)(F)F)C=C4)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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