AMA-37 is an ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK), demonstrating an IC50 value of 0.27 μM for this target. In addition, it shows moderate inhibitory activity against phosphoinositide 3-kinase isoforms with IC50 values of 32 μM for p110α, 3.7 μM for p110β, and 22 μM for p110γ. This compound is suitable for research applications focusing on DNA repair mechanisms and cancer therapeutics, where modulation of DNA-PK activity may be beneficial.
AMA-37 is an ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK), demonstrating an IC50 value of 0.27 μM for this target. In addition, it shows moderate inhibitory activity against phosphoinositide 3-kinase isoforms with IC50 values of 32 μM for p110α, 3.7 μM for p110β, and 22 μM for p110γ. This compound is suitable for research applications focusing on DNA repair mechanisms and cancer therapeutics, where modulation of DNA-PK activity may be beneficial.
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