Fig. 1 · Structure
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Amakusamine
RANKL/RANK Inhibitor
Amakusamine is a RANKL/RANK inhibitor that effectively suppresses the RANKL-induced formation of multinuclear osteoclasts. This compound demonstrates an IC50 value of 10.5 μM in RAW264.7 cells, indicating its capacity to modulate osteoclastogenesis. Amakusamine is useful for research in bone metabolism and osteoporosis, providing insights into osteoclast differentiation and function.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2923661-84-9 |
| Applications | RANKL/RANK Inhibitor |
| Formula | C9H5Br2NO2 |
| Molecular Weight | 318.95 |
| SMILES | BrC1=C2OCOC2=C(C3=C1C=CN3)Br |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.