Fig. 1 · Structure
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Ambrisentan-d10
ETAR Antagonist
Ambrisentan-d10 is a deuterated form of Ambrisentan and acts as a selective antagonist of the endothelin type A receptor (ETAR). This compound exhibits potent inhibition of ETAR, making it valuable for research on cardiovascular and pulmonary conditions associated with endothelin signaling. Its deuterated profile may enhance metabolic stability and facilitate studies in pharmacokinetics and drug metabolism.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1046116-27-1 |
| Applications | ETAR Antagonist |
| Formula | C22H12D10N2O4 |
| Molecular Weight | 388.48 |
| Synonyms | BSF 208075-d10; LU 208075-d10 |
| SMILES | CC1=NC(O[C@H](C(O)=O)C(C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])(C3=C([2H])C([2H])=C([2H])C([2H])=C3[2H])OC)=NC(C)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.