Fig. 1 · Structure
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Americanin A
Anticancer Agent
Americanin A is a neolignan that exhibits potent anticancer activity by activating the ATM and ATR pathways, which in turn initiate critical signaling cascades involving Chk1, Chk2, and the tumor suppressor p53. It selectively targets Skp2 for degradation, leading to the stabilization of the cyclin-dependent kinase inhibitor p27, and suppresses the activity of Cyclin B1 and cdc2 to inhibit cell cycle progression into mitosis. Additionally, Americanin A induces apoptosis through the production of excessive reactive oxygen species (ROS) and demonstrates efficacy against colorectal cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 69506-79-2 |
| Applications | Anticancer Agent |
| Formula | C18H16O6 |
| Molecular Weight | 328.32 |
| SMILES | OC[C@H]1[C@H](C2=CC(O)=C(C=C2)O)OC3=CC=C(/C=C/C=O)C=C3O1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.