AMG-221 is a selective inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with a Ki value of 12.8 nM as determined by biochemical scintillation proximity assays and an IC50 of 10.1 nM in cell-based assays. This compound demonstrates potential for modulating cortisol metabolism, making it a valuable tool for research into type 2 diabetes and related metabolic disorders.
AMG-221 is a selective inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with a Ki value of 12.8 nM as determined by biochemical scintillation proximity assays and an IC50 of 10.1 nM in cell-based assays. This compound demonstrates potential for modulating cortisol metabolism, making it a valuable tool for research into type 2 diabetes and related metabolic disorders.
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