AMG 511 is a potent pan-inhibitor of class I phosphoinositide 3-kinases (PI3Ks), demonstrating inhibitory constants (Kis) of 4 nM, 6 nM, 2 nM, and 1 nM for PI3Kα, β, δ, and γ, respectively. This compound effectively suppresses PI3K signaling, as evidenced by a decrease in phosphorylated Akt (Ser473). AMG 511 has shown significant anti-tumor activity in mouse models of glioblastoma, making it a valuable tool for cancer research and therapeutic development.
AMG 511 is a potent pan-inhibitor of class I phosphoinositide 3-kinases (PI3Ks), demonstrating inhibitory constants (Kis) of 4 nM, 6 nM, 2 nM, and 1 nM for PI3Kα, β, δ, and γ, respectively. This compound effectively suppresses PI3K signaling, as evidenced by a decrease in phosphorylated Akt (Ser473). AMG 511 has shown significant anti-tumor activity in mouse models of glioblastoma, making it a valuable tool for cancer research and therapeutic development.
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