AMG410 is a non-covalent, selective pan-KRAS inhibitor with IC₅₀ values of 1–4 nM against KRAS^G12D, KRAS^G12V, and KRAS^G13D. It demonstrates over 100-fold selectivity against HRAS and NRAS. AMG410 functions as a dual-state inhibitor, binding both GDP-bound (K\_d = 1 nM) and GTP-bound (K\_d = 22 nM) KRAS, effectively blocking signaling independent of the nucleotide state. It also inhibits proliferation in wild-type KRAS-amplified tumor cells and is suitable for research in colorectal, pancreatic, and lung cancers.
AMG410 is a non-covalent, selective pan-KRAS inhibitor with IC₅₀ values of 1–4 nM against KRAS^G12D, KRAS^G12V, and KRAS^G13D. It demonstrates over 100-fold selectivity against HRAS and NRAS. AMG410 functions as a dual-state inhibitor, binding both GDP-bound (K\_d = 1 nM) and GTP-bound (K\_d = 22 nM) KRAS, effectively blocking signaling independent of the nucleotide state. It also inhibits proliferation in wild-type KRAS-amplified tumor cells and is suitable for research in colorectal, pancreatic, and lung cancers.
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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