AMI-1

Catalog No.: A15916

Hmt1p/PRMT1 Inhibitor

AMI-1

AMI-1 Chemical Structure

CAS NO. 20324-87-2

AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 uM and 8.8 uM for yeast Hmt1p and human PRMT1, respectively.

Availability: In stock

Package Price Qty
5 mg
$75.00
10 mg
$140.00
25 mg
$280.00
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Biological Activity

AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 uM and 8.8 uM for yeast Hmt1p and human PRMT1, respectively.
Targets
yeast Hmt1p human PRMT1
3.0 μM8.8 μM
In vitro (25°C) DMSO Warmed: 89 mg/mL (162.27 mM)
Water 9 mg/mL (16.41 mM)
Ethanol Insoluble
In vivo PBS 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.23 mL 91.17 mL 182.33 mL
0.5 mM 3.65 mL 18.23 mL 36.47 mL
1 mM 1.82 mL 9.12 mL 18.23 mL
5 mM 0.36 mL 1.82 mL 3.65 mL

*The above data is based on the productmolecular weight 548.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15916
Actions Inhibitor
CAS No. 20324-87-2
Formula C21H14N2Na2O9S2
M. Wt 548.45
Purity >98%
Synonyms AMI 1, AMI1, AMI-1 disodium salt
SMILES O=C(NC1=CC2=CC(S(=O)([O-])=O)=CC(O)=C2C=C1)NC3=CC4=CC(S(=O)([O-])=O)=CC(O)=C4C=C3.[Na+].[Na+]
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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