Fig. 1 · Structure
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Aminoglutethimide
P-450-Dependent Hydroxylase Inhibitor
Aminoglutethimide is a selective inhibitor of cytochrome P-450-dependent hydroxylases, notably affecting aromatase and other steroidogenic enzymes. It significantly disrupts steroid hormone biosynthesis pathways, leading to decreased cortisol production, with reported IC50 values of 0.3 μM for aromatase and varying effects on other enzymes. This compound is employed in research related to endocrine disorders, including Cushing's syndrome and breast cancer, making it a valuable reagent for studies focused on steroid hormone regulation and therapeutic interventions in related conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 125-84-8 |
| Applications | P-450-Dependent Hydroxylase Inhibitor |
| Formula | C13H16N2O2 |
| Molecular Weight | 232.28 |
| Synonyms | DL-Aminoglutethimide |
| SMILES | O=C(C(CC)(C1=CC=C(N)C=C1)CC2)NC2=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.