Fig. 1 · Structure
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(Aminooxy)acetamide-Val-Cit-PAB-MMAE
ADC Intermediate
(Aminooxy)acetamide-Val-Cit-PAB-MMAE is an ADC intermediate crucial for the synthesis of antibody-drug conjugates (ADCs). It facilitates the formation of an oxime bond with polyamide, resulting in the production of the MMAE polyamide conjugate. This conjugate can subsequently be linked to Trastuzumab, enhancing targeted therapeutic delivery. This reagent is essential for research in targeted cancer therapies and drug development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2446645-88-9 |
| Applications | ADC Intermediate |
| Formula | C60H97N11O14 |
| Molecular Weight | 1196.48 |
| SMILES | C[C@@H](C(N[C@H](C)[C@H](C1=CC=CC=C1)O)=O)[C@H]([C@@](CCC2)([H])N2C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC(C=C3)=CC=C3NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CON)=O)=O)=O)=O)=O)=O)=O)OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.