Fig. 1 · Structure
Documents & Downloads
Aminopterin N-hydroxysuccinimide ester
Methotrexate Influx Carrier Inhibitor
Aminopterin N-hydroxysuccinimide ester serves as an irreversible inhibitor of the Methotrexate influx carrier. This compound is instrumental in research related to rheumatoid arthritis and various cancers, including acute lymphoblastic leukemia. Its mechanism allows for the evaluation of therapeutic strategies targeting folate transport pathways, enhancing the understanding of drug resistance and efficacy in cancer treatment.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 98457-88-6 |
| Applications | Methotrexate Influx Carrier Inhibitor |
| Formula | C24H27N9O8 |
| Molecular Weight | 569.53 |
| Synonyms | NHS-Methotrexate |
| SMILES | NC1=NC(N)=NC2=C1N=C(CN(C3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O)C)C=N2.O=C4N(C(CC4)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.