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Amorphigenin

c-Fos/NFATc1 Inhibitor

Amorphigenin is a c-Fos and NFATc1 inhibitor that plays a critical role in the regulation of osteoclast differentiation. This compound acts by suppressing the expression of key factors in activated T cells, thereby mitigating inflammation-related bone loss. Additionally, Amorphigenin promotes the degradation of melanosome proteins through an AMPK-dependent autophagy pathway, independent of mTOR signaling. Its protective effects on bone mass and reduction of bone erosion in murine models make it valuable for investigating inflammatory bone diseases, postmenopausal osteoporosis, and disorders of skin pigmentation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	4208-09-7
Applications	c-Fos/NFATc1 Inhibitor
Formula	C₂₃H₂₂O₇
Molecular Weight	410.42
SMILES	O=C1[C@@]2([C@]([H])(OC3=C1C=CC4=C3C[C@@H](O4)C(CO)=C)COC5=C2C=C(C(OC)=C5)OC)[H]

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.