Fig. 1 · Structure
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Amotosalen
DNA/RNA-Crosslinking Psoralen Compound
Amotosalen is a light-activated psoralen compound that crosslinks DNA and RNA, serving as an effective agent for pathogen neutralization. Upon exposure to ultraviolet light, Amotosalen binds to nucleic acids, resulting in permanent crosslinking that inhibits replication and halts the proliferation of donor T cells. This compound is particularly valuable in research focused on blood system pathogen reduction technologies and the mechanisms underlying graft-versus-host disease (GVHD).
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 161262-29-9 |
| Applications | DNA/RNA-Crosslinking Psoralen Compound |
| Formula | C17H19NO4 |
| Molecular Weight | 301.34 |
| Synonyms | S-59 free base |
| SMILES | O=C1OC2=C(C)C(OC(C)=C3COCCN)=C3C=C2C(C)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.