Fig. 1 · Structure
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AMRI-59
Prxi Inhibitor
AMRI-59 is a potent inhibitor of Peroxiredoxin I (PrxI), primarily utilized in the study of parasitic infections and cancer therapeutics. By increasing cellular reactive oxygen species (ROS), AMRI-59 activates mitochondrial signaling pathways and apoptosis signal-regulated kinase 1, which promotes apoptotic processes in A549 human lung adenocarcinoma cells. This compound demonstrates significant antitumor activity while exhibiting minimal acute toxicity, making it a valuable tool for cancer research and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 923515-92-8 |
| Applications | Prxi Inhibitor |
| Formula | C25H27N3O2 |
| Molecular Weight | 401.50 |
| SMILES | O=C(N1CCC(CC2=CC=C(N3C=CC=C3)C=C2)CC1)NC4=CC=CC(C(C)=O)=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.