Fig. 1 · Structure

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Amustaline dihydrochloride

Pathogen Inactivation Agent

Amustaline dihydrochloride is a nucleic acid-targeted alkylator that functions as an effective pathogen inactivation agent, particularly for blood components containing red blood cells. This compound comprises an acridine anchor that intercalates with nucleic acids, a bis-alkylator group that interacts with nucleophiles, and a flexible linker with a labile ester bond that hydrolyzes at neutral pH, yielding non-reactive by-products. Amustaline dihydrochloride is primarily utilized in research applications focused on ensuring blood safety and improving transfusion practices.

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Specifications

Manufacturer Adooq Bioscience
CAS Number 210584-54-6
Applications Pathogen Inactivation Agent
Formula C22H27Cl4N3O2
Molecular Weight 507.28
Synonyms S-303 dihydrochloride
SMILES
O=C(CCNC1=C2C=CC=CC2=NC3=CC=CC=C31)OCCN(CCCl)CCCl.[H]Cl.[H]Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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