Fig. 1 · Structure
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AMX-883
BRD9 Molecular Glue Degrader
AMX-883 is a selective, orally active molecular glue degrader targeting BRD9, facilitating cellular differentiation in acute myeloid leukemia (AML). Demonstrating high selectivity for BRD9 over other bromodomain-containing proteins, AMX-883 employs DCAF16 as its E3 ligase, distinguishing it from conventional degraders. This compound is valuable for investigating the mechanistic underpinnings of AML and exploring new therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 3102636-19-8 |
| Applications | BRD9 Molecular Glue Degrader |
| Formula | C45H58FN5O5 |
| Molecular Weight | 767.97 |
| SMILES | COC(C=C(C(C(C)=C1C)=CN(C)C1=O)C=C2OC)=C2CN(CC3)CC4(CC4)N3CC5=C6C([C@H](N(CC6)C(/C(C#N)=C/C(C)(C)CF)=O)C(C)C)=CC(OC)=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.