Fig. 1 · Structure
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AMXT-1501 tetrahydrochloride
Polyamine Transport Inhibitor
AMXT-1501 tetrahydrochloride is an orally active inhibitor of polyamine transport, primarily targeting polyamine uptake in cells. This compound has been shown to effectively block tumor growth in immunocompetent mice, suggesting the importance of immune response in its efficacy. Additionally, the combination of AMXT-1501 with DFMO promotes caspase-3 mediated apoptosis in neuroblastoma cell lines, highlighting its potential for therapeutic applications in cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2444815-84-1 |
| Applications | Polyamine Transport Inhibitor |
| Formula | C32H72Cl4N6O2 |
| Molecular Weight | 714.77 |
| SMILES | CCCCCCCCCCCCCCCC(NCCCC[C@@H](N)C(NCCCNCCCCNCCCN)=O)=O.Cl.Cl.Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.