Fig. 1 · Structure
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AMY-101
C3 Inhibitor
AMY-101 is a potent peptidic inhibitor of the central complement component C3, with a dissociation constant (KD) of 0.5 nM. This compound has demonstrated efficacy in inhibiting naturally occurring periodontitis in non-human primates. Additionally, AMY-101 exhibits significant anti-inflammatory activity in models of severe pneumonia associated with COVID-19, making it a valuable tool for research in inflammatory diseases and complement activation pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1427001-89-5 |
| Applications | C3 Inhibitor |
| Formula | C83H117N23O18S2 |
| Molecular Weight | 1789.09 |
| Synonyms | Cp40 |
| SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC(=O)CN(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2cn(C)c3ccccc23)NC(=O)[C@@H](NC1=O)C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)C(N)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.