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Amyloid 17-42

Active Compound

Amyloid 17-42 (Aβ(17-42)) is an active compound derived from the cleavage of the amyloid precursor protein (APP) by alpha- and gamma-secretases. This peptide is a significant component of diffuse plaques in Alzheimer's disease and pre-amyloid deposits in Down's syndrome. Amyloid 17-42 is known to induce neuronal apoptosis through activation of the Fas-like/caspase-8 pathway, making it a valuable reagent for research on neurodegenerative diseases and related apoptotic mechanisms.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	155178-13-5
Applications	Active Compound
Formula	C₁₁₉H₁₉₄N₂₈O₃₃S
Molecular Weight	2577.05
Synonyms	Aβ(17-42)
SMILES	[C@H](CC1=CC=CC=C1)(C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)C)=O)[C@H](CC)C)=O)[C@H](C)C)=O)C(C)C)=O)=O)=O)[C@@H](C)C)=O)CCSC)=O)CC(C)C)=O)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)C)=O)=O)CCCCN)=O)CC(N)=O)=O)CO)=O)=O)[C@@H](C)C)=O)CC(O)=O)=O)CCC(O)=O)=O)C)=O)=O)NC([C@@H](NC([C@H](CC(C)C)N)=O)[C@@H](C)C)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.