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AN11736

CPSF3 Inhibitor

AN11736 is a specific inhibitor of CPSF3, targeting the endonuclease activity crucial for mRNA maturation in trypanosomes. This compound demonstrates potent anti-trypsin activity with IC50 values of 0.14 nM against T. congolense and 1.3 nM against T. vivax. AN11736 shows significant efficacy in mouse and cattle models, making it a valuable tool for studying trypanosomiasis and exploring potential therapeutic interventions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2152662-85-4
Applications	CPSF3 Inhibitor
Formula	C₂₁H₂₃BFNO₅
Molecular Weight	399.22
SMILES	OB1OCC2=CC=C(C(N[C@@H](C(C)C)C(OCC3=CC=C(F)C=C3)=O)=O)C(C)=C21

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.