Fig. 1 · Structure
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AN317
nAChR Agonist
AN317 is a selective agonist for the α6β2-containing nicotinic acetylcholine receptor (nAChR), exhibiting Ki values of 6.2 nM for the α6/α3β2β3 receptor and 4.1 nM for the α4β2 receptor. This compound effectively induces dopamine release in rat striatum synaptosomes and enhances dopaminergic neuronal activity in the substantia nigra. Additionally, AN317 demonstrates neuroprotective effects against dopamine neurotoxin MPP+ and possesses favorable pharmacokinetic properties, including the ability to cross the blood-brain barrier. Research applications include studies in neuropharmacology and the exploration of mechanisms underlying dopaminergic signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 946074-35-7 |
| Applications | nAChR Agonist |
| Formula | C13H19N3 |
| Molecular Weight | 217.31 |
| SMILES | CN(C(CCC1)C2)C1CN2C3=CC=CN=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.