Fig. 1 · Structure
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Anabasine hydrochloride
nAChR Agonist
Anabasine hydrochloride is a potent agonist of nicotinic acetylcholine receptors (nAChRs). This alkaloid, derived from tobacco (Nicotiana), functions as a full agonist, inducing depolarization in TE671 cells that endogenously express human fetal muscle-type nAChRs (EC50 = 0.7 µM). Anabasine hydrochloride is relevant for research applications in neurobiology and toxicology, particularly in studies exploring nAChR signaling and muscle contraction mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 53912-89-3 |
| Applications | nAChR Agonist |
| Formula | C10H15ClN2 |
| Molecular Weight | 198.69 |
| Synonyms | (S)-Anabasine hydrochloride; (+)-Anabasine hydrochloride |
| SMILES | [H]Cl.C1([C@H]2NCCCC2)=CC=CN=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.