Fig. 1 · Structure
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And1-IN-1
And1 Inhibitor
And1-IN-1 is a selective inhibitor of And1, exhibiting an IC50 of 2.08 μM. It binds specifically to the N-terminus of And1, resulting in a conformational change that facilitates the interaction of And1 with the E3 ligase CUL4B, leading to ubiquitin-mediated degradation. This compound demonstrates significant anticancer activity, effectively suppressing growth across various cancer types and resensitizing platinum-resistant ovarian cancer cells to platinum-based therapies. And1-IN-1 is valuable for research in ovarian and breast cancer studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2451028-69-4 |
| Applications | And1 Inhibitor |
| Formula | C15H11BCl2O2 |
| Molecular Weight | 304.96 |
| SMILES | OB1OCC2=CC(/C=C/C3=CC=C(Cl)C(Cl)=C3)=CC=C21 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.